4,6 The Cause Of High Ldl Levels Has Not Been Clearly Established But Dietary ...
4,6 The cause of high LDL levels has not been clearly established but dietary factors are likely to be involved. There is evidence that a diet high in saturated, but lacking in polyunsaturated, fat may contribute to high cholesterol levels. There is relatively little actual cholesterol in the diet, but saturated fat is converted into cholesterol in the liver.4,6 Lack of exercise as a risk factor Lack of exercise is a proven risk factor for the development of coronary heart disease. Overall, the risk is a third less in people who exercise compared to those who don't.8 It seems that physical exercise has a protective effect on the development of coronary heart disease. The mechanism underlying this has not been fully elucidated but certain hypotheses have been put forward. Exercise may increase levels of good HDL cholesterol and also reduce the blood clotting which occurs within atherosclerotic arteries and causes further blockage. Exercise might also help enlarge the coronary arteries and hence increase blood supply to the heart. In order to gain full health benefits from exercise in the reduction of coronary heart disease risk, five bouts of moderate physical activity per week, each lasting a minimum of 30 minutes, are recommended. Conclusion Coronary heart disease is a serious condition caused by the build-up of fatty deposits within the walls of the vital arteries that supply blood to the heart. Coronary heart disease is the major cause of death in Western societies but to a large extent is preventable. Recognising the key risk factors which contribute to the development of atherosclerosis is an important step towards reducing the overall incidence of coronary heart disease. References Walton J, Beeson PB, Bodley Scott R, 1986. The Oxford Companion to Medicine: Volume I, A-M. Oxford: Oxford University Press. Higgins M, 2001. Patients, families and populations at high risk for coronary heart disease. European Heart Journal, 22: 1682-1690. Association of the British Pharmaceutical Industry, 2005. Hitting the Target: Medicines and Coronary Heart Disease and Stroke. Available at: http://www.abpi.org.uk/publications/publication_details/hitting_target/section5b.asp [Accessed 14 March 2005]. Julian DG & Campbell Cowan J, 1992. Cardiology: Sixth Edition. London: Bailliere Tindal. Vander AJ, Sherman JH, Luciano DS, 1994. Human Physiology: The Mechanisms of Body Function. International Edition: McGraw-Hill. Edwards CRW & Bouchier IAD (Eds), 1991. Davidson's Principles and Practice of Medicine: Sixteenth Edition. London: Churchill Livingston. Singh VN, 2005. Coronary Heart Disease. Emedicine. Available from: http://www.emedicinehealth.com/articles/10951-1.asp [Accessed 14 March 2005]. PRODIGY Guidance, 2004. Preventing Heart Disease and Stroke. Patient information leaflet. Available at: http://www.prodigy.nhs.uk/clinicalguidance/releasedguidance/webBrowser/pils/PL82.htm [Accessed 14 March 2005].
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